Synthesis and Functionalization of Dextran–Based Single–Chain Nanoparticles in Aqueous Media
Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and mild conditions. Radiolabeling of the resulting biocompatible materials allowed the study of lung deposition of aqueous aerosols after intratracheal nebulization by means of single-photon emission computed tomography (SPECT), demonstrating their potential use as imaging contrast agents.
Raquel Gracia, Marco Marradi, Unai Cossío, Ana Belen Benito, Adrián Pérez-San Vicente, Vanessa Gómez-Vallejo, Hans J Grande, Jordi Llop and Iraida Loinaz
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